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The selected TBV-08 aptamer markedly improves inhibition of thrombin activity. We plotted the absorbance (OD350) of the thrombin-mediated fibrinogen cleavage reaction at steady state in the presence of varying concentrations of different inhibitory molecules. These data were fitted to a four-parameter logistic model and scaled from 0 to 1. TBV-08 proved more effective than the direct thrombin inhibitor Argatroban, the parental aptamer Bock-15 and the 16T bivalent aptamer.
