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. 2012 Dec 17;209(13):2339–2350. doi: 10.1084/jem.20120873

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© 2012 Rai et al.

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Figure 3. — RAGE activates ERK in RH-7777 in rat hepatoma cells. (A) Real-time PCR for LPA receptors 1–5 and RAGE mRNA transcripts was performed in RH-7777 cells and normalized to 18s transcript levels. The graphs show relative fold of LPA receptor transcripts in RH-7777 cells. Assays were performed in triplicate and results shown are representative of two independent experiments. (B) Quantified levels of phosphorylated/total ERK are shown in RH-7777 rat hepatoma cells transfected with control vector, full-length RAGE, and upon 10 µM LPA stimulation at the indicated times. Representative results from triplicate experiments and at least two independent experiments are shown. *, P < 0.05. Error bars represent SD.