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. 2012 Dec 17;209(13):2383–2394. doi: 10.1084/jem.20112631

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© 2012 Nishida et al.

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Figure 3. — Pathogenic role of CAG in colitis of CD45RB model. CD4⁺CD45RB^high naive T cells were purified from the spleen of WT (WT>RAG) versus T/C2GnT Tg (C2GnT>RAG) mice, and they were adoptively transferred i.v. into Rag1^−/− mice. The recipients were sacrificed at 8 wk after transfer. (A) Representative colonic histologies (×10 objective) are shown. Colon of donor WT mouse is shown as normal control. Bars, 200 µm. (B) Disease scores evaluated by a combination of macroscopic and microscopic examinations are summarized. Each dot represents individual recipient. **, P < 0.0001. (C) Expression levels of IL-1β in the colonic tissues from WT mice and from Rag1^−/− mice with transfer of WT-derived (WT>RAG) versus T/C2GnT tg–derived (C2GnT>RAG) CD4⁺ T cells are shown. n = 6/each group. *, P < 0.005.