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. 2012 Dec 1;9:262. doi: 10.1186/1742-2094-9-262

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Copyright ©2012 Bethel-Brown et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt cell signaling pathways lie upstream of platelet-derived growth factor (PDGF)-BB induced nuclear factor κB (NFκB) in astrocytes. The nuclear fractions of A172 cells transfected with wild-type (WT) or dominant-negative (DN) forms of mitogen-activated protein (MAP) kinase kinase (MEK) and Akt were subjected to western blot analysis for NFκB. (A) Transfection with DN-MEK but not WT-MEK resulted in abrogation of PDGF-BB-mediated induction of NFκB phosphorylation. (B) Transduction with DN-Akt but not WT-Akt also resulted in abrogation of PDGF-BB-mediated induction of NFκB phosphorylation. All the data are presented as mean ± SD of three individual experiments. ***P <0.001 versus control group, ###P <0.001 versus PDGF-BB-treated group.