Table 2.
Effect of LPS + PHA stimulation on the release of cytokines (Release of IL-1β, TNF-α, IL-6, IL-10 and IFN-γ in whole blood from wild type subjects (P2X7WT) and subjects homozygous for the Glu496Ala polymorphism (P2X7MUT)a))
| |
Unstimulated |
p-value |
Stimulated |
p-value |
||
|---|---|---|---|---|---|---|
| P2X7WT | P2X7MUT | P2X7WT | P2X7MUT | |||
|
IL-1β |
2.2 ± 0.16 |
2.6 ± 0.35 |
0.381 |
5,644 ± 3,261 |
3,440 ± 1,647 |
0.529 |
|
TNF-α |
6.6 ± 1.04 |
7.1 ± 0.33 |
0.694 |
7,784 ± 3,470 |
5,173 ± 1,380 |
0.504 |
|
IL-6 |
2.5 ± 0.21 |
2.5 ± 0.35 |
0.965 |
13,922 ± 5,790 |
19,804 ± 8,003 |
0.064 |
|
IL-10 |
2.4 ± 0.21 |
2.0 ± 0.10 |
0.190 |
291 ± 104 |
305 ± 167 |
0.968 |
| IFN-γ | 15.4 ± 3.93 | 13.4 ± 6.38 | 0.792 | 701 ± 283 | 791 ± 144 | 0.766 |
a)Data are shown as mean ± SEM.