Table 5. SNP-SNP interactions identified by Statistical Epistasis Network Analysis.
| SNP a | SNP b | N | (%) | N | (%) | Odds Ratio (95%CI) | P interact | ||
| DNA Repair | |||||||||
| PMS1_26 | TT/CT | NBS1_01b | CG/GG | 826 | (95.8) | 530 | (93.8) | 1.0 (ref) | |
| rs1233258 | CC | rs1805794 | CC | 36 | (4.2) | 35 | (6.2) | 4.15 (1.79–9.66) | 0.0009 |
| g.IVS5-1656C>T | g.Ex5-32C>G p.E185Q | ||||||||
| Immune | |||||||||
| IRF3_01 | AA/GG | IL6_01 | CC/GG | 698 | (59.8) | 492 | (62.6) | 1.0 (ref) | |
| rs2304204 | AG | rs1800795 | CG | 165 | (14.1) | 71 | (9.0) | 0.39 (0.24–0.617) | <0.0001 |
| g.-924A>G | g.Ex2C>G | ||||||||
| Metabolism | |||||||||
| COMT_28b | AA/GG | APOB_07 | CT/TT | 619 | (53.0) | 436 | (55.5) | 1.0 (ref) | |
| rs6518591 | AG | rs1800481 | CC | 234 | (20.1) | 122 | (15.5) | 0.35 (0.21–0.58) | <0.0001 |
| g.IVS2+1485T>C | g.-392C>T | ||||||||
| PTGS2_05 | AA/GG | ABCC4_04 | CC/TT | 788 | (67.5) | 516 | (65.7) | 1.0 (ref) | |
| rs689466 | AG | rs3765535 | CT | 68 | (5.8) | 44 | (5.6) | 0.23 (0.11–0.485) | 0.0001 |
| g.Ex2A>G | g.IVS17-65T>C |