Figure 5. Notch1 functions in a cell autonomous manner.

(A) Representative images of orthotopic tumors in Pdx1-cre;Notch^lox/+ and Pdx1-Cre;Notch1^lox/lox mice. Tumor cells (T) are seen adjacent to normal pancreatic tissue. Scale bar, 300 µm (B) Quantitative analysis of pancreas weight and percentage of tumor volume in Pdx1-Cre;Notch^lox/+(n = 5) and Pdx1-Cre;Notch1^lox/lox (n = 6) mice 2 weeks after orthotopic injections. Box plots depict median values, lower and upper quartiles, and maximum and minimum observed values.