Table 2. The classification accuracy, sensitivity, and specificity of the support vector machine (SVM) classifiers are given for distinguishing normal controls (NC) and subjects with Alzheimer's disease (AD), NC and subjects with mild cognitive impairment (MCI), and subjects with MCI and AD.

	NC.vs. AD	NC.vs. MCI	MCI.vs. AD
Hippocampal Volumes and Shapes
Hp volumes	65.5% (CI: 64.4%∼66.6%) Sensitivity = 57.8%, Specificity = 73.3%	61.9% (CI: 61%∼62.8%) Sensitivity = 57.7%, Specificity = 66.1%	42.3% (CI:32.2%∼52.3%) Sensitivity = 45.3%, Specificity = 39.2%
Hp shapes	79.2% (CI: 78.5%∼80%) Sensitivity = 75.8%, Specificity = 82.8%	67.4% (CI: 66.2%∼68.6%) Sensitivity = 64%, Specificity = 70.8%	57.2% (CI: 51.7%∼62.8%) Sensitivity = 59.9%, Specificity = 54.5%
Lateral Ventricular Volumes and Shapes
LV volumes	65.5% (CI: 64.9%∼66.1%) Sensitivity = 58.8% Specificity = 72.3%	63.1% (CI: 62%∼64.2%) Sensitivity = 50.9%, Specificity = 75.3%	30.4% (CI: 18.8%∼42%) Sensitivity = 21.2% Specificity = 39.7%
LV shapes	61.5% (CI: 59.2%∼63.9%) Sensitivity = 59.2%, Specificity = 63.9%	59% (CI: 56.1%∼62%) Sensitivity = 53.6%, Specificity = 64.4%	60.1% (CI:57.1%∼63.1%) Sensitivity = 62%, Specificity = 58.3%
CSF
CSF markers	81.4% (CI: 80.3%∼82.5%) Sensitivity = 87.4%, Specificity = 74.9%	68.4% (CI: 67.8%∼69%) Sensitivity = 66.7%, Specificity = 70.1%	61.3% (CI: 59.4%∼63.2%) Sensitivity = 84.3%, specificity = 38.3%
Combination
CSF, Hp volumes, LV volumes	85.4% (CI: 84.3%∼86.5%) Sensitivity = 88.8%, Specificity = 82%	72% (CI: 70.5%∼73.5%) Sensitivity = 70.1%, Specificity = 73.9%	60.9% (CI: 59.1%∼62.8%) Sensitivity = 80.4%, Specificity = 41.4%
CSF, Hp shapes, LV shapes	92.2% (CI: 91%∼93.5%) Sensitivity = 94.7%, Specificity = 89.8%	70.3% (CI: 68.6%∼72.9%) Sensitivity = 69.5%, specificity = 71.9%	69.6% (CI: 66.4%∼72.8%) Sensitivity = 70.7%, Specificity = 68.6%

The volumes and shapes of the hippocampus (Hp) and lateral ventricles (LV) as well as cerebral spinal fluid (CSF) markers are respectively used as features in the SVM.