. 2012 Dec 19;7(12):e51748. doi: 10.1371/journal.pone.0051748

Table 1. Serum proteins potentially relevant to NSCLC confirmed by IMDL and label free quantification in the discovery phase.

Protein Name	Gene symbol	IPI ID	SwissPort/Trembl	Normalized average peptide hits^a			Referrences of NSCLC^b
				N	AD	SCC
Up-regulated in AD and SCC
Alpha-1-antitrypsin	SERPINA1	IPI00553177	P01009	1396.7	2393.4	2460.0	[31], [56]
C4b-binding protein alpha chain	C4BPA	IPI00021727	P04003	164.8	264.5	264.1	[57], [58]
C-reactive protein	CRP	IPI00022389	P02741	0.0	15.2	3.5	[32]
Haptoglobin	HP	IPI00641737	P00738	337.2	764.3	693.3	[29], [32], [56], [57]
Haptoglobin-related protein	HPR	IPI00607707	P00739	93.4	369.5	295.9	[32]
Hemoglobin subunit alpha	HBA1/HBA2	IPI00410714	P69905	6.8	38.3	21.5	[30]
Hemopexin	HPX	IPI00022488	P02790	374.2	703.3	680.5	[29]
Leucine-rich alpha-2-glycoprotein	LRG1	IPI00022417	P02750	24.7	73.6	47.4	[32]
Prothrombin	F2	IPI00019568	P00734	156.4	185.8	203.9	[32]
Serotransferrin	TF	IPI00022463	P02787	2076.6	2781.6	2931.8	[56]
Serum amyloid A protein	SAA1	IPI00552578	P02735	2.2	87.8	51.3	[29], [59]
Serum amyloid A2	SAA2	IPI00006146	P02735	0.6	88.9	37.4	[60]
Transthyretin	TTR	IPI00022432	P02766	326.1	507.0	779.5	[30], [31], [60]
Up-regulated in AD
Complement component 4a	C4A	IPI00744893	P0C0L4	55.4	99.5	53.8	[32]
IGHA1 protein	IGHA1	IPI00166866		288.3	516.6	366.4	[58]
Ig alpha-2 chain C region	IGHA2	IPI00641229	P01877	153.5	355.6	253.4	[58]
IGHA2 protein	IGHA2	IPI00644497		45.8	170.0	109.7
Up-regulated in SCC
Apolipoprotein C-III	APOC3	IPI00657670	P02656	1.0	3.5	5.3	[31]
Ceruloplasmin	CP	IPI00017601	P00450	167.1	61.7	179.2	[57]
Clusterin	CLU	IPI00291262	P10909	63.2	64.5	86.6	[32], [58]
Up-regulated in N
Alpha-2-macroglobulin	A2M	IPI00478003	P01023	3356.6	2808.8	2802.3	[32]
Angiotensinogen	AGT	IPI00032220	P01019	235.8	127.6	121.4	[32]
Antithrombin-III	SERPINC1	IPI00032179	P01008	747.5	341.0	587.6	[29]
Apolipoprotein L1	APOL1	IPI00186903	O14791	28.9	11.7	21.5	[61]
Complement C3	C3	IPI00783987	P01024	3380.1	3341.6	2639.9	[32], [58]
Gelsolin	GSN	IPI00026314	P06396	101.3	47.5	67.2	[32], [61]
Plasminogen	PLG	IPI00019580	P00747	370.3	247.6	279.3	[32]
Tetranectin	CLEC3B	IPI00009028	P05452	8.7	1.9	3.7	[32]

Averaged PSMs (peptide hits) in Normal (N), AD and SCC group.

Reference listed were closely related to NSCLC and all reported the identical up or down regulation trend with our results.