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. 2012 Dec 19;7(12):e51683. doi: 10.1371/journal.pone.0051683

Figure 2. Apoptosis-Dependent Definition of CM Turnover in the Kajstura Model.

Figure 2

The hybrid model was parameterized in accordance with the Kajstura published values for Cardiac Stem Cell number, cycling frequency, mitosis duration, and expansion exponenent. Turnover was computed as newly formed CM divided by either a constant CM density (5,000,000 CM per 10 g tissue, as in the Kajstura publication) or a variable CM density determined by iterative production and destruction of CM using the aforementioned Kajstura CM formation parameters in conjunction with the Kajstura CM apoptosis parameters. The simulation is performed for A) Males and B) Females.