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. Author manuscript; available in PMC: 2012 Dec 19.
Published in final edited form as: Artif Cells Blood Substit Immobil Biotechnol. 2008;36(5):421–430. doi: 10.1080/10731190802369763

Figure 7.

Figure 7

Histology of renal tubular system in rats toploading with NanoHb (a), LactRing (b), SFHb (c), PolyHb (d) or RBC (e). Under light microscope, in the groups a, b, d and e, the tubular system showed normal, no protein or other sediments within the tubular lumens. However, in the rats infused with SFHb (d), the proximal tubular necrosis was observed (arrows), and necrotic cell debris presented in the lumens of proximal tubules (arrow head), showing the ongoing necrosis in the kidney, although 3 weeks after SFHB injection. H&E staining, ×400.