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. Author manuscript; available in PMC: 2012 Dec 19.
Published in final edited form as: Mol Cancer Res. 2009 Jun 2;7(6):863–869. doi: 10.1158/1541-7786.MCR-08-0418

Figure 6. Mdm2-a/p53-heterozygous mice develop aggressive mammary tumors, which have stabilized MDM2-A expression.

Figure 6

(A) Micrographs of Mdm2-a/p53-heterozygous mammary carcinomas. The upper panel shows a mammary carcinoma with soft tissue invasion, 4× magnification. The lower panel shows mammary carcinoma metastases in the lung parenchyma, 3.2× magnification. (B) Western blot analysis of MDM2-A expression in normal mammary tissue (lanes 1–3) and mammary tumor tissue (lanes 4–6) isolated from p53-heterozygous (lane 1) and Mdm2-a/p53-heterozygous transgenic mice (lanes 2–6).