Fig. 2.

Effect of Corydalis tuber (CT) on chronic constriction injury (CCI)-induced mechanical allodynia (MA) and thermal hyperalgesia (TH). CT at a dose of 30 mg/kg significantly reduced mechanical allodynia when it was treated in the induction and maintenance phases (A, B). In a thermal hyperalgesia test, CT at doses of 10 and 30 mg/kg increased the paw withdrawal latency in the maintenance phase (D), but not induction phase (C). Pregabalin (30 mg/kg) was used as a positive control drug. Lines in each panel indicate the treatment period of CT or pregabalin. ^*p<0.05 and ^**p<0.01 control vs CR. ^#p<0.05 and ^##p<0.01 control vs pregabalin.