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. 2012 Dec 10;16(6):387–392. doi: 10.4196/kjpp.2012.16.6.387

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Copyright © 2012 The Korean Physiological Society and The Korean Society of Pharmacology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — Effect of Cyperi rhizoma (CR) and Corydalis tuber (CT) on chronic constriction injury (CCI)-induced phosphorylation of NMDA receptor NR1 subunit (pNR1) in maintenance phase. The number of pNR-1 positive neurons was significantly increased by CCI surgery (B) as compared with Sham group (A). Treatment of CR or CT (30 mg/kg) in the maintenance phase did not affect the chronic constriction injury-induced pNR1 in the superficial dorsal horn (SDH), nucleus proprius (NP) and neck of dorsal horn (NECK). The pNR1 immunoreactivity was observed in Sham (A), control (B), CR (C) and CT (D)-treated groups. Panel (E) shows a diagram depicting the location of the different spinal cord regions analyzed in this study. Results of each group are represented in panel (F). Inserted panels show a magnified image of rectangles in panel A, B, C, and D, respectively. The black arrow heads indicate representative pNR1 neurons. The number of animals is 3 in each group. Scale bar=200 µm.