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. 2012 Dec 20;3:472. doi: 10.3389/fphys.2012.00472

Figure 4.

Figure 4

Zyxin silencing reduced pulling force response in VSMC. The AFM probe with FN-coated beads were placed into contact with the cell surface of VSMC (zyxin-shRNA or control). AFM pulling forces were then applied to the bead from the cell surface in z-axis. The displacement (nm) of the bead over 250 s was shown to indicate the VSMC response to the pulling force. (n = 5, p < 0.004 vs. control). (B) Percentage of cell compensation as an indicator of quantified cellular micro-myogenic response. (C) Comparison of the apparent pulling elasticity indicating no significant change in the FN-focal adhesion strength. Error bars represent standard error of the mean. *p < 0.05.