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. 2013 Jan;58(1):155–168. doi: 10.1016/j.jhep.2012.08.002

Table 1.

Summary of hepatobiliary transporters in hepatocytes, their function, regulation through nuclear receptors and genetic alterations. See supplementary material for all references in this table.

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ABCG5/8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5/8; BAs, bile acids; BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2; BRIC, benign recurrent intrahepatic cholestasis; BSEP (ABCB11), bile salt export pump; CA, cholic acid; CAR (NR1I3), constitutive androstane receptor; FXR (NR1H4), farnesoid X receptor/bile acid receptor; GR (NR3C1), glucocorticoid receptor; HCC, hepatocellular carcinoma; HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha; IBD, inflammatory bowel disease, ICP, intrahepatic cholestasis of pregnancy; LXRα (NR1H3), liver X receptor alpha; MDR1 (ABCB1), p-glycoprotein, multidrug resistance protein 1, ATP-binding cassette, subfamily B, member 1; MDR2/3 (ABCB4), multidrug resistance protein 2/3; MRP2 (ABCC2), multidrug resistanceassociated protein 2, ATP-binding cassette, subfamily C, member 2; MRP3 (ABCC3) multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3; MRP4 (ABCC4) multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4; NAFLD, non-alcoholic fatty liver disease; NTCP (SLC10A1), sodium/taurocholate cotransporting polypeptide, solute carrier family 10, member 1; OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2; OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1; OATP1B3 (SLCO1B3, OATP8, SLC21A8) solute carrier organic anion transporter family, member 1B3; OSTα/β, organic solute transporter alpha/beta; PBC, primary biliary cirrhosis; PFIC, progressive familial intrahepatic cholestasis; PPARα (NR1C1), peroxisome proliferator-activated receptor alpha; PSC, primary sclerosing cholangitis; PXR (NR1I2), pregnane X receptor; RXRα (NR2B1), retinoid X receptor alpha; SHP (NR0B2), short heterodimer partner; VDR (NR1I1), vitamin D receptor.