Fig. 2.

Schematic illustration of theoretical SAC_NS effects on (A) rabbit and (B) murine isolated SAN cell AP. Experimental V_m recordings from both species show the relation of electrophysiological parameters (MDP, MSP, threshold for AP excitation, THR) and SAC_NS reversal potential (E_SAC,NS). The time periods during which SAC_NS activity would either accelerate (↑ΔV) or slow (↓ΔV) intrinsic changes in V_m are indicated. In rabbit, SAC_NS would accelerate intrinsic changes in V_m during 70.8% of AP duration, while in mouse this would occur over only 46.4% of AP duration.

From Cooper and Ravens (2011), with permission.