Table 1.

Patient (n=67) characteristics

Patient Demographics
Sex	Male	48
	Female	19
Race	Caucasian	54
	African American	10
	Other	3
Age at diagnosis(years) [median (range)]		11.8 (2.2–18.7)
Tumor description
Diagnosis	Germinoma	42
	NGGCT	25
Location	Pineal	38
	Suprasellar	22
	Bifocal	7
	Metastatic at presentation	21
Initial Treatment
		Germinoma (42)	NGGCT (25)	Total (67)
Surgery		37	15	52
	Biopsy	26	5a	31
	PR	3	2	5
	STR	6	3	9
	NTR/GTR	2	5b	7
	No Surgery	5c	10d	15
RT		41	24	65e
	Focal only	2f	0	2
	CSI+Focal Boost	36	22	58
	Whole Brain+Focal Boost	0	1g	1
	WVI + Focal Boost	3	1	4
	No RT	1	1	2
	Additional Sterotactic radiosurgery	0	4	4
Chemotherapy		18	23h	41
Follow-up
Time of follow-up (years) [median (range)]	Median	9.3 (0.4–24.4)
Status	NEDi	57
	DOD	5
	DNODj	5

Abbreviations: NGGCT, non-germinomatous germ cell tumor; PR, partial resection;, STR, subtotal resection; NTR, near total resection; GTR, gross total resection; RT, radiation therapy; CSI, cranio-spinal irradiation; WVI, whole ventricular irradiation; NED, no evidence of disease; DOD, died of disease; DNOD died not of disease.

^aFive patients with NGGCT had a biopsy and then soon after had second surgery [partial (n=1), STR (n=1), NTR/GTR (n=3)] and for them the surgery after biopsy was considered the definite surgery; therefore, these patients were not included in the patient numbers for biopsy.

^bFive patients had GTR/NTR surgery after RT(n=1), chemo (n=3), or both (n=1).

^cThree patients were diagnosed by elevated bHCG and two by bifocal location.

^dTen patients were diagnosed by elevated markers alone, with no indication for surgery.

^eOne patient with germinoma and 1 with NNGCT did not receive RT, as they were 2 and 3 years old, respectively.

^fOne patient treated outside St. Jude, and 1 patient treated in the low-risk branch of POG 9530 protocol.

^gPatient treated in 1985.

^hTwo patients treated in 1985 did not receive chemotherapy.

^IFour patients were considered NED on the basis of negative markers but still had a residual mass likely consisting of benign fibrous tissue.

^jFive patients considered DNOD [endocrinopathies (n=2), second malignancy (n=1), VP shunt sepsis (n=1), and suicide (n=1)].