Table 1.
Nicotine metabolites for each drug × time cell (N=17).
| Drug phase |
||||||
|---|---|---|---|---|---|---|
| Placebo |
Varenicline |
|||||
| Day 1 | Day 7 | Day 21 | Day 1 | Day 7 | Day 21 | |
| Total metabolitesa | 110 (14) | 74 (11) | 79 (14) | 111 (15) | 106 (13) | 81 (9) |
| Nicotineb | 20.0 (6) | 12.4 (3) | 18.0 (6) | 24.0 (5) | 17.1 (4) | 13.8 (3) |
| Cotinine | 19.0 (2) | 13.8 (2) | 12.0 (2) | 16.9 (2) | 16.8 (2) | 14.0 (2) |
| CO (ppm) | 30 (4) | 28.6 (3) | 25 (2) | 23.2 (2) | 24.1 (2) | 22 (2) |
CO: carbon monoxide; ppm: parts per million. Values are mean (SE), adjusted for age and nicotine dependence; all units are μM except where noted.
a
Time, p<0.05.
b
Drug × time interaction, p<0.10.