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. 2012 Dec 4;4:333–338. doi: 10.2147/CLEP.S38229

Table 1.

Definitions used as reference standards for this validation study

Cbl deficiency anemia, strict definition (1 and [A or B or C]) Cbl deficiency anemia, wide definition (1 and [A or B or C or D or E]) Cbl deficiency without concomitant anemia (A or B or C or D or E)

  1. Hemoglobin < 7.0 mmol/L (women)/, 8.0 mmol/L (men)

    1. MMA > 0.75 μmol

    2. Cbl < 125 pmol/L

    3. MMA > 0.28 μmol/L AND Cbl 125–250 pmol/L

  1. Hemoglobin < 7.0 mmol/L (women)/, 8.0 mmol/L (men)

    1. MMA > 0.75 μmol

    2. Cbl < 125 pmol/L

    3. MMA > 0.28 μmol/L AND Cbl 125–250 pmol/L

    4. Cbl 125–250 pmol/L AND tHcy >12.0 μmol/L

    5. Cbl 125–250 pmol/L AND MCV > 98 fL (macrocytosis)

  1. MMA > 0.75 μmol

  2. Cbl < 125 pmol/L

  3. MMA > 0.28 μmol/L AND Cbl 125–250 pmol/L

  4. Cbl 125–250 pmol/L AND tHcy > 12.0 μmol/L

  5. Cbl 125–250 pmol/L AND MCV > 98 fL (macrocytosis)

Notes: Definitions of cobalamin deficiency anemia and cobalamin deficiency without concomitant anemia. The fulfilling biochemical criteria are outlined.

Abbreviations: Cbl, cobalamin; MCV, mean corpuscular volume; MMA, methylmalonic acid; tHcy, total homocysteine.