Figure 2.

Escitalopram showed 5-HT transporter occupancy that outlived its plasma concentration.

Notes: Escitalopram (10 mg) was administered once daily for 10 consecutive days (the first 5 days are shown) to six healthy men. The 5-HT transporter occupancy rate was determined in the midbrain-hypothalamus region. The 5-HT transporter occupancy rate of escitalopram peaked at 80% and the occupancy half-life was 130 hours.

Copyright © 2007, Springer-Verlag. Adapted with permission from Klein N, Sacher J, Geiss-Granadia T, et al. Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study. Psychopharmacology (Berl). 2007;191(2):333–339.¹³