Table 3.

Treatment-emergent side effects that occurred by discharge day

Side effects	AD-naïve	Overall	NMD	MD	BD
	n = 80	n = 71	n = 35	n = 17	n = 19
Sleepiness	13.75	61.97**	71.43	58.82	47.37
Malaise	5.00	39.44**	42.86	47.06	26.32
Dry mouth	8.75	76.06**	80.00	88.24	57.89
Constipation	11.25	69.01**	54.29	52.94	110.53
Dysuria	3.75	36.62**	31.43	52.94	31.58
Dizziness	5.00	49.30**	34.29	29.41	94.74
Cephalalgia	5.00	28.17**	22.86	35.29	31.58
Hidrosis	2.50	15.49**	17.14	11.76	15.79
Anorexia	3.75	9.86*	11.43	11.76	5.26
Tremor	0.00	8.45	8.57	5.88	10.53
Akathisia	0.00	5.63	5.71	5.88	5.26

Notes: Values are expressed as % of the total number of patients in each group;

^*P < 0.05,

^**P < 0.01 versus antidepressant-naïve patients (Mann–Whitney U test).

Abbreviations: AD, antidepressant; MD, melancholic depression; NMD, nonmelancholic depression; BD, bipolar depression.