FIG. 1.

Examples of the effects of reactive oxygen species (ROS) on various channel currents. (A, B) Hydrogen peroxide (H₂O₂) increased the Ca⁺² currents from the L-type Ca²⁺ channels (I_CaL) and the persistent Na⁺ currents from the cardiac Na⁺ channels (I_NaP). (C) Dihydroxyfumarate (DHF), an oxidant, decreased the inward rectifier K⁺ currents (I_Kr) from the Kv11.1 channels. All these currents were measured in the guinea pig myocytes, and are taken from (44, 167, 249), with copywrite permissions, respectively. The arrows indicate differences in the currents.