Figure 5.

ADNIV disease timeline and progression. (A) ADNIV occurs in five stages (I–V), each lasting approximately 10 years and beginning at 10–30 years of age. Clinical features are listed below each stage. (B) Twin A progressed to more severe stage III disease with some asymmetry between eyes. Her epiretinal membranes and cystoid macular edema were worse in the left eye and required surgery. There was also more peripheral field loss. (C) Twin B progressed to less severe stage III disease with asymmetry between eyes. Cystoid macular edema was worse in the right eye.

Abbreviations: ADNIV, autosomal dominant neovascular inflammatory vitreoretinopathy; OD, right eye; OS, left eye.