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Disease-modifying treatments: modulation of tau deposition.
| Interfering with tau deposition | Interfering with tau phosphorylation | Immunotherapy |
|---|---|---|
| Methylene blue: phase II trial (+) | Tau kinase inhibitors (lithium: phase I trial (−) in AD (+) in MCI ) | Vaccination: preclinical trials |
, encouraging results; −, disappointing results.
AD, Alzheimer’s disease; MCI, mild cognitive impairment.1
