Figure 10.

View of the ligand binding at the human D2 dopamine receptor. SV 293 and SV-III-130s are shown in a stick model format, with the carbon atoms in cyan for SV 293 and magenta for SV-III-130s. Several potential contact amino acid residues for the quinolinone moiety of SV-III-130s in the D2 E1/E2 cleft are labeled, including, L94 in TMS II, W100 in E1, and the disulfide bridge between C182 in EL2 and C107 in TMS III. Residue numbering is based upon the sequence of the human D2 dopamine receptor.