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Comparison of ligand binding at the D3/D2 E2 loop chimeric receptor and the wild type D3 dopamine receptor. The binding of SV 293 (cyan) and SV-III-130s (magenta) at the D3 receptor, in alignment with the D3/D2E2 loop chimera, is shown. The receptors are shown in cartoon representation with D3 in green and chimera in gray. The side chains of the second extracellular (EL2) loops in both receptors are shown in stick model, with important structural features noted.
