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. 2012 Oct 12;3(12):1050–1062. doi: 10.1021/cn300142q

Figure 5.

Figure 5

Evaluation of the effect of SV 293 on GIRK channel activation in HEK cells stably transfected with human D2long and GIRK2 channel subunit. (A) Representative channel activation profile for the effect of quinpirole (40 nM) and SV 293 (60 nM) on GIRK2 channel activation. Essentially no activity is observed when SV 293 is applied alone. (B) Representative channel activation profile for the ability of SV 293 (60 nM) to attenuate the effect of the full agonist quinpirole (40 nM). (C) Finally, a bar is shown that summarizes the relative effects of quinipirole (40 nM), SV 293 (60 nM), and the combination of quinpirole and SV 293 on the ability to activate GIRK2 channels in HEK cells expressing dopamine D2long receptors and GIRK2 channels. Values for each bar represent the mean current amplitude relative to quinpirole control value ± SEM for n = 4 independent experiments.