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. 2012 Oct 12;3(12):1050–1062. doi: 10.1021/cn300142q

Figure 6.

Figure 6

Evaluation of the effect of SV-III-130s on GIRK channel activation in HEK cells stably transfected with human D2long and GIRK2 channel subunit. (A) Representative channel activation profile for the effect of quinpirole (40 nM) and SV-III-130s (2 nM) on GIRK2 channel activation. Essentially no activity is observed for SV-III-130s. (B) Representative channel activation profile for the ability of SV-III-130s (2 nM) to attenuate the effect of the full agonist quinpirole (40 nM). (C) Finally, a bar graph is shown that summarizes the relative effects of quinipirole (40 nM), SV-III-130s (2 nM), and the combination of quinpirole and SV-III-130s on the ability to activate GIRK2 channels in HEK cells coexpressing the human dopamine D2long receptor. Values for each bar represent the mean of the current amplitude relative to quinpirole control value ± SEM for n = 4 independent experiments.