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. 2012 Sep 9;3(12):1025–1036. doi: 10.1021/cn300103e

Table 3. Ki values of Atropine, VU0364572, and VU0357017 Derived from Competition Binding Experimentsa.

graphic file with name cn-2012-00103e_0011.jpg

compd rM1Ki μM (±SEM) rM2Ki μM (±SEM) rM3Ki μM (±SEM) rM4Ki μM (±SEM) rM5Ki μM (±SEM)
VU0364572 45.9 (10.1) 19.7 (16.9) 77.5 (8.41) 30.3 (13.2) 26.6 (0.56)
VU0357017 9.91 (1.6) 21.4 (15.7) 55.3 (21.5) 35.0 (12.9) 50.0 (13.6)
atropine 0.001 (0.000) 0.003 (0.000) 0.001 (0.000) 0.002 (0.000) 0.003 (0.001)
a

Data represents values determined from displacement of [3H]-NMS (0.3 nM) in cell membranes isolated from CHO cells stably expressing rM1–rM5 receptors. Values represent the mean ± SEM of three to five independent experiments performed in duplicate.