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Novel mutation in cdh23 in Cdh23nmf308/nmf308 mice. (A) Nucleotide mutation (208T>C, arrow indicated) in cdh23 in Cdh23nmf308/nmf308 causing a CDH23 sequence alteration (70 S-P, red indicated). (B) Sequence alterations in CDH23 (70 S-P) induced a change in secondary structure of the protein as analyzed by GOR IV secondary structure prediction. Only the first 140 amino acids of the protein are shown, e: extended strand; c: random coil.
