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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: Gene. 2012 Feb 4;499(2):309–317. doi: 10.1016/j.gene.2012.01.084

Fig. 3.

Fig. 3

Cdh23nmf308/nmf308 mice exhibited hearing loss at wide range of sound frequencies. (A) By mating Cdh23nmf308/nmf308 mice with those of C3H (+/+), which had normal hearing, the F1 progenies (nm/+) were generated and then crossed. Among the 51 F2 offspring (five-month old), 13 (nm/nm) had higher ABR thresholds and 38 (nm/+) had normal ABR thresholds when stimulated with different sound frequencies. (B) Auditory-evoked brainstem response (ABRs) exhibited threshold elevation from 30 to 100 dB SPL at frequencies over 8 kHz in three-month old Cdh23nmf308/nmf308 mice. (C) Three-month old Cdh23nmf308/nmf308 mice manifested hearing loss at wide range of sound frequencies.