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Cdh23nmf308/nmf308 mice exhibited time course of DPOAE. (A) DPOAE exhibited increasing threshold at high frequencies (≥16 kHz). At five-weeks of age, the Cdh23nmf308/nmf308 mice manifested hearing loss at wide range of sound frequencies at 22 weeks of age compared with B6mice with same age. (B) At 3 months of age the Cdh23nmf308/nmf308 mice manifested hearing loss at wide range of sound frequencies.
