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. Author manuscript; available in PMC: 2012 Dec 20.
Published in final edited form as: Gene Ther. 2011 Jun 30;19(1):78–85. doi: 10.1038/gt.2011.64

Figure 4. Prevention of humoral response to transgene and capsid following intra muscular administration.

Figure 4

Figure 4

Figure 4

(A) Attenuation of humoral immunity to transgene after intra muscular delivery of 4×1011vg/kg rAAV2/5 CAGG hFIX. Transgene levels measured by ELISA at day 21 n=3 mean ±SEM. (B) Attenuation of humoral response to capsid after intra muscular administration of vector. Anti-AAV5 antibodies detected by ELISA at day 21 n=3 mean ±SEM. (C) Anti –hFIX antibody response is prevented with the use of transient immunosupression. hFIX antibody was measured by ELISA on day 21 n=3 mean ±SEM.