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SIRT1 is an NAD+-dependent protein deacetylase SIRT1 splits NAD+ into nicotinamide and ADP-ribose, then transfers the acetyl group from the protein substrate to the 2′-OH group of ribose ring in the ADP-ribose molecule. Nutritional, hormonal, and environmental signals can modulate the deacetylase activity of SIRT1 through changes of the cellular NAD+ levels, alterations in the expression of SIRT1 protein, or posttranslational modifications/interactions on SIRT1 protein.
