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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Free Radic Biol Med. 2012 Jun 19;53(5):1139–1151. doi: 10.1016/j.freeradbiomed.2012.06.012

Figure 7. Targeted decreases in p47phox expression in neuronal cells attenuates apoptotic cell death in rat hippocampal slice cultures.

Figure 7

Rat hippocampal slice cultures were transduced with the AAV-SYN-1-p47phoxAS, an AAV-SYN-1null construct, or were untransduced. After 7 days slices were exposed to OGD and the effect on cleaved caspase-3 (A & B), and TUNEL positive nuclei (C & D) determined. Representative images are shown. Decreasing p47phox expression reduces the OGD-mediated increases in cleaved caspase-3 (B) and the increase in TUNEL positive nuclei (D). Values are presented as mean ± S.E from 4 independent experiments using 24 pooled slices per experiment. *p<0.05 vs. uninfected no OGD, †p<0.05 vs. OGD exposed untransduced slices.