Skip to main content
. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Free Radic Biol Med. 2012 Jun 19;53(5):1139–1151. doi: 10.1016/j.freeradbiomed.2012.06.012

Figure 9. gp91ds-tat treatment attenuates NADPH oxidase activity and superoxide generation in the neonatal rat brain exposed to hypoxia-ischemia.

Figure 9

P7 neonatal rats were pre-treated with gp91ds-tat, the scrambled control peptide, or vehicle then exposed to HI. Two hours after HI, NADPH oxidase activity (A) was determined in the left and right hemispheres of the brain. Superoxide levels were also determined using both EPR (B) and DHE oxidation (C & D). There is a significant increase in both NADPH oxidase activity and superoxide levels in the right hemisphere of the neonatal brain that is attenuated by gp91ds-tat, but not the scrambled peptide. Values are presented as mean ± S.D. from 5–6 animals per group. *p<0.05 vs. left hemisphere, †p<0.05 vs. HI + vehicle.