Table 2. Comparison of GSK3-β rs334558*C Carriers with T/T Homozygotes.
| Axial diffusivity | No. of voxels and signal peaks (X, Y, Z) | White matter tracts |
|---|---|---|
| T/T=11.92±1.59 C carriers=12.37±1.6 | 7618 −20 −17 40 (L corona radiata) | Forceps minor Genu of corpus callosum Body of corpus callosum Splenium of corpus callosum Forceps major Cingulum bundle Uncinate fasciculus L Superior longitudinal fasciculus L Inferior longitudinal fasciculus L Inferior fronto-occipital fasciculus L Anterior thalamic radiation L Corticospinal tract L Anterior corona radiata L Superior corona radiata L Posterior corona radiata L |
| 3114 21 −26 40 (R corona radiata) | Forceps minor Body of corpus callosum Cingulum bundle R Superior longitudinal fasciculus R Superior corona radiata R Corticospinal tract R | |
| 2740 37 −44 30 (R superior longitudinal fasciculus) | Splenium of corpus callosum Forceps major Cingulum bundle R Hippocampus R Superior longitudinal fasciculus R Inferior longitudinal fasciculus R Posterior thalamic radiation R Inferior fronto-occipital fasciculus R | |
| Mean diffusivity | No of voxels and signal peaks (X, Y, Z) | White matter tracts |
| T/T=7.3±0.38 C carriers=7.56±0.35 | 2620 −26 20 26 (L uncinate fasciculus) | Forceps minor Body of corpus callosum Cingulum L Uncinate fasciculus L Inferior fronto-occipital fasciculus L Anterior thalamic radiation L Corticospinal tract L Superior corona radiata L |
| 1820 23 −13 7 (R posterior limb of internal capsule) | Cerebral peduncle R Posterior limb of internal capsule R Corticospinal tract R External capsule R Anterior thalamic radiation R Anterior limb of internal capsule R Superior longitudinal fasciculus R | |
| 286 −28 23 32 (L anterior thalamic radiation) | Superior longitudinal fasciculus L |
In the first column, values of the DTI measures of AD and MD (means±SD) are given for for regions showing maximal differences of TBSS values (signal peak). The second column shows dimensions of clusters (number of voxels, mm3) and localization of signal peaks (MNI coordinates). The third column lists the WM tracts significantly affected by genotype in the clusters.