Table 3.
Serotonin transporter (SLC6A4 ) single nucleotide polymorphisms (SNPs) investigated in patients with schizophrenia and control subjects
|
SNP |
Base |
MAF |
Genotype counts (schizophrenia/control) |
Allele association |
Genotype association |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
|
Allele 1 |
|
Allele 2 |
|
OR |
|
|
OR |
OR |
|
| (1/2) | Homozyogotes | Heterozygotes | Homozygotes | p-value | 2 vs 1 | p-value | 12 vs 11 | 22 vs 11 | ||||
| Rs1042173 |
A/C |
0.46 |
223/410 |
402/770 |
207/291 |
0.083 |
|
1.11 |
0.022 |
|
0.93 |
1.27 |
| Rs4583306 |
A/G |
0.42 |
276/475 |
410/755 |
173/237 |
0.020 |
|
1.16 |
0.020 |
|
1.04 |
1.40 |
| Rs140700 |
C/T |
0.09 |
689/1233 |
140/221 |
2/10 |
0.435 |
|
1.09 |
0.171 |
|
1.17 |
0.39 |
| Rs2020942 |
C/T |
0.14 |
313/528 |
390/714 |
128/228 |
0.359 |
|
0.94 |
0.518 |
|
0.90 |
0.91 |
| Rs12150214 |
G/C |
0.18 |
595/982 |
219/438 |
21/46 |
0.123 |
|
0.88 |
0.282 |
|
0.86 |
0.83 |
| Rs4251417 |
C/T |
0.09 |
673/1204 |
148/257 |
9/7 |
0.214 |
|
1.14 |
0.123 |
|
1.07 |
2.78 |
| Rs16965628 | G/C | 0.06 | 753/1310 | 77/152 | 1/9 | 0.192 | 0.83 | 0.125 | 0.91 | 0.19 | ||
The table shows nominal allele and genotype association results with gender and country as covariates.
Nominal allele and genotype association results are reported with gender and country as covariates. MAF, minor allele frequencies in control individuals (allele 2 in the table).
Nominally significant; after correction for multiple testing using permutation test, all P- values > 0.10.