Table 3.
Genotype frequencies for five p21 SNPs in cervical cancer patients and controls
| |
Patients |
controls |
|
|
|---|---|---|---|---|
| |
(n=393) |
(n=434) |
|
|
| SNP | No. (%) | No. (%) | OR (95% CI) | P* |
| rs762623 |
|
|
|
|
| AA |
9 (2.3) |
16 (3.7) |
0.627 (0.272-1.447) |
0.274 |
| AG |
133 (33.8) |
135 (31.1) |
1.096(0.816-1.472) |
0.542 |
| GG |
251 (63.9) |
283 (65.2) |
reference |
|
| rs2395655 |
|
|
|
|
| AA |
96 (24.4) |
92 (21.2) |
1.393 (0.936-2.074) |
0.102 |
| AG |
207 (52.7) |
222 (51.2) |
1.245 (0.892-1.738) |
0.197 |
| GG |
90 (22.9) |
120 (27.6) |
reference |
|
| rs1801270 |
|
|
|
|
| AA |
76 (19.3) |
117 (27.0) |
0.583(0.399-0.853) |
0.005 |
| AC |
179 (45.5) |
195 (44.9) |
0.811 (0.590-1.114) |
0.196 |
| CC |
138 (35.1) |
110 (28.1) |
reference |
|
| rs3176352 |
|
|
|
|
| CC |
37 (9.4) |
56 (12.9) |
0.637 (0.339-1.016) |
0.058 |
| CG |
177 (45.0) |
205 (47.2) |
0.883 (0.623-1.114) |
0.218 |
| GG |
179 (45.5) |
173 (39.9) |
reference |
|
| rs1059234 |
|
|
|
|
| CC |
131 (33.3) |
102 (23.5) |
1.392 (0.957-2.023) |
0.083 |
| CT |
160 (40.7) |
221 (50.9) |
0.786 (0.560-1.101) |
0.161 |
| TT | 102 (26.0) | 111 (25.6) | reference |
* P value was adjusted for age and smoking by multiple logistic regressions. After Bonferroni correction, significant P value was <0.01.