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. 2012 Oct 9;9:22. doi: 10.1186/2045-8118-9-22

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Copyright ©2012 Swiderski et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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BBS mutant mouse SFO ultrastructure. TEM micrographs of coronal sections of 3.5 wk-old wild-type (A), Bbs1^M390R/M390R (B) and Bbs6^−/− SFO show an intact ependymal layer with zona adherens junctions between cells and numerous motile cilia on the apical surface. Transition zones (arrows in C) appear normal in 8 mo.-old Bbs6^−/− mice. Electron-dense and vesicle-like material is seen in Bbs1^M390R/M390R and Bbs6^−/− SFO cilia in the presence (G) and absence (D-F) of axonemal disruption. Arrows point to axonemes. Bars equal 2 μm (A, B,C) and 0.2 μm (D-H).

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