Table 1.
Association of Ku80 expression with clinical characteristics of 106 patients with lung adenocarcinoma
| Characteristics | patients (n = 106) |
Ku80 mRNA level |
|
P |
Ku80 protein level |
|
P |
|---|---|---|---|---|---|---|---|
| Low (n = 28) | High (n = 78) | Low ( n = 23) | High (n = 83) | ||||
| Age at diagnosis of lung AC |
|
|
|
0.202 |
|
|
|
| mean ± SD |
58.33 ± 10.50 |
57.45 ± 9.96 |
60.79 ± 11.71 |
|
|
|
|
| Gender |
|
|
|
0.371 |
|
|
0.151 |
| Male |
43(40.6) |
9(32.1) |
34(43.6) |
|
6(26.1) |
37(40.6) |
|
| Female |
63(59.4) |
19(67.9) |
44(56.4) |
|
17(73.9) |
46(55.4) |
|
| Smoking status |
|
|
|
0.238 |
|
|
0.13 |
| Never |
32(30.2) |
11(39.3) |
21(26.9) |
|
10(43.5) |
22(26.5) |
|
| Former and current smokers |
74(69.8) |
17(60.7) |
57(73.1) |
|
13(56.5) |
61(73.5) |
|
| Tumor grade |
|
|
|
0.062 |
|
|
0.114 |
| Well differentiated |
36(34.0) |
15(53.6) |
21(34.0) |
|
12(52.2) |
24(28.9) |
|
| Moderately differentiated |
32(30.2) |
7(25.0) |
32(30.2) |
|
5(21.7) |
27(32.5) |
|
| Poorly differentiated |
38(35.8) |
6(21.4) |
32(35.8) |
|
6(26.1) |
32(38.6) |
|
| Lymph node metastasis |
|
|
0.001 |
|
|
0.001 |
|
| Positive |
73(68.9) |
11(39.3) |
62(79.5) |
|
6(26.1) |
67(80.7) |
|
| Negative |
33(31.1) |
17(60.7) |
16(20.5) |
|
17(73.9) |
16(19.3) |
|
| Disease stage |
|
|
|
0.014 |
|
|
0.017 |
| I |
23(21.7) |
10(35.7) |
13(16.7) |
|
10(43.5) |
13(21.7) |
|
| II |
57(53.8) |
13(46.4) |
44(56.4) |
|
9(39.1) |
48(53.8) |
|
| III | 26(24.5) | 5(17.9) | 21(26.9) | 4(17.4) | 22(26.5) | ||