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. 2012 Dec 4;12:571. doi: 10.1186/1471-2407-12-571

Figure 4.

Figure 4

Starvation sensitizes human lung carcinoma A549 xenografts to CDDP in vivo.A, Western blot results with antibodies against phospho Chk2-T68, Chk2, γ-H2AX and p53 for protein extracts from untreated control A549 cells and those treated with CDDP alone, serum starvation alone, or both together are shown. β-Actin was used as loading control. B, growth curves of A549 tumors in the untreated control animal group and those treated with CDDP, STS, or both together (n=6/group) (** P<0.011). C, complete tumor remission is observed only with the CDDP treatment combined with STS. The arrows in (B) indicate the time points of individual treatments.