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. 2012 Dec 20;8(12):e1003133. doi: 10.1371/journal.pgen.1003133

Table 2. Genes down-regulated in daf-10(m79) mutants versus wild-type animals.

Gene Brief description p value Fold change qRT-PCR data DAF-16 target? DAF-12 target? Pathogen-responsive? Tissue expression?
T21E8.2/pgp-7 P-glycoprotein, ABC transporter 7.97E-05 0.08 Down in daf-10(m79) G Tail, intestine [67], [68]
C05A9.1/pgp-5 P-glycoprotein, ABC transporter 2.44E-04 0.10 Down in daf-10(m79) B G Intestine [68]
K01A2.3 Unknown 0.004 0.14 Intestine, muscle [69], [70]
C07G3.2/irg-1 Riboflavin synthesis protein, DUF1768 0.003 0.15 Not induced by PA14 in daf-10(m79) F, G Intestinal (enriched, I)Intestinal, induced by PA14 [71]
B0024.1/col-149 Collagen 0.001 0.17
Y49G5A.1 Serine protease inhibitor 0.002 0.18 Down in daf-10(m79), osm-5(p813)Regulated by daf-12 B* D G*
W06G6.12 Unknown 0.004 0.20
T21E8.1/pgp-6 P-glycoprotein, ABC transporter 0.002 0.21 G Neuronal (expressed, H)Neurons, intestine [68]
C32H11.12/dod-24 Unknown, DUF141, Age 0.002 0.21 Down in daf-10(m79), osm-5(p813)Regulated by daf-12 A, B D F, G
T24C4.4 Unknown, DUF1164 0.003 0.23 Down in daf-10(m79)Induction by PA14 is reduced in daf-10(m79) B, C F, G Intestinal (expressed, I)
C32H11.4 Unknown, DUF141 0.003 0.25 Down in daf-10(m79), osm-5(p813)Induction by PA14 is reduced in daf-10(m79)Regulated by daf-12 A, B, C D F, G
C10H11.6/ugt-26 UDP-glucuronoyl transferase 0.005 0.25 B G
C03H5.1/clec-10 C-type lectin 0.004 0.26 B F*, G* Intestinal (expressed, I)
F55G11.2 Unknown, DUF141 0.004 0.26 Down in daf-10(m79), osm-5(p813)Regulated by daf-12 B, C D F, G
F38A5.9/nspb-5 Unknown, worm specific, DUF1459 0.018 0.27
K10D11.1/dod-17 Unknown, DUF141, Age 0.007 0.27 Down in daf-10(m79), osm-5(p813)Induction by PA14 is reduced in daf-10(m79)Regulated by daf-12 A, B, C D F, G Intestinal (expressed, I)
T20D4.3 Peptide N glycanase, worm specific, DUF750 0.009 0.28 G*
C17H12.6 Unknown, DUF141 0.007 0.29 Down in daf-10(m79), osm-5(p813)Regulated by daf-12 B D F, G Intestinal (enriched, I)
Y22D7AR.10 Histone acetyltransferase 0.006 0.29
T20D4.5 Peptide N-glycanase, DUF750 0.008 0.30
F42A9.6 Unknown, possible function in germline 0.006 0.30 Commonly expressed in germline, muscle and intestine (I)Neuronal (expressed, H)
Y53F4B.11 Unknown 0.011 0.31
T02E1.7 SURF4 family, putative cargo protein 0.015 0.31
Y45F10C.2 Unknown, DUF1505 0.007 0.31 Uterus [72]
F35E12.5 Unknown, DUF141 0.008 0.31 A, B, C D G
Y69A2AR.25 Unknown 0.011 0.32 Up in osm-5(p813) D
C29F9.14/C29F9.9 Unknown, 7TM receptor 0.009 0.32 C*
ZK6.11 Transmembrane glycoprotein, DUF274, regulates fat accumulation, aging 0.011 0.32 Down in daf-10(m79) A, B, C G Intestinal (enriched, I)
F19B2.5 Helicase-like transcription factor 0.013 0.33 F, G Intestinal (expressed, I)
C29F9.3 Unknown 0.010 0.33 Intestinal (enriched, I)
F55G11.3 Pseudogene 0.014 0.34 Down in daf-10(m79), osm-5(p813)Regulated by daf-12 B D G
F31F4.15/fbxa-72 F-box protein 0.017 0.34 Down in daf-10(m79), osm-5(p813)Regulated by daf-12 B D G* Intestinal (enriched, I)
C08F11.12 Unknown, DUF1505 0.015 0.35
K11H12.4 Unknown, DUF274, predicted GPI-anchor 0.017 0.35 Not repeated B, C G
C17H12.8 Unknown, DUF141 0.016 0.37 A G Intestinal (enriched, I)
C14C6.5 ShK toxin domain 0.015 0.38 F Intestinal (expressed, I)
D1025.6/nspc-16 Unknown, worm specific 0.015 0.38
C33C12.4 Unknown, worm specific, Emb 0.020 0.38 Intestinal (expressed, I)
Y58A7A.3 RNAse III family, Zn-finger protein 0.018 0.39 B G
T19D12.4 Unknown, Esp 0.017 0.40 Down in daf-10(m79) A. B F, G Intestinal (enriched, I)
Y69A2AR.13 Unknown 0.019 0.40
C29F3.7 Unknown, DUF141, Gro 0.020 0.44 B F, G Intestinal (enriched, I)
T24B8.5 ShK toxin domain 0.019 0.56 Down in daf-10(m79), osm-5(p813) A, B F
R06C1.4 RNA binding protein 0.019 0.56 B Intestinal (expressed, I)
C55B7.4/acdh-1 Acyl CoA dehydrogenase, Esp, Age 0.018 0.56 F*, G* Intestinal (expressed, I)
C36C5.5 Worm-specific Cys-rich secreted protein, DUF19 0.019 0.57
F36D1.4 Unknown 0.019 0.57 D*
C06G3.12 Transposon 0.019 0.57
Y69E1A.8 Unknown 0.017 0.57
F25H5.8 Member of UPF0057, stress responsive protein 0.018 0.57
F38E1.3 Protein kinase 0.020 0.57
ZK1251.1/htas-1 Histone H2A variant 0.017 0.57 D* Germline [73]
T22A3.2/hsp-12.1 Member of Hsp20 protein family 0.019 0.57 Muscle [69]
K08E7.4 Unknown 0.019 0.57
K10C2.3 Aspartyl protease 0.020 0.57 Down in daf-10(m79) D F, G
C54F6.13/nhx-3 Sodium/proton exchanger 0.019 0.69 D Hypodermis, reproductive system [74]

A = down-regulated in a daf-16-dependent fashion in daf-2 mutants, Murphy et al., 2003 [31].

B = down-regulated in a daf-16-dependent fashion in daf-2 mutants, McElwee et al., 2004 [35].

B* = up-regulated in a daf-16-dependent fashion in daf-2 mutants, McElwee et al., 2004 [35].

C = down-regulated in a daf-16-dependent fashion in daf-2 mutants, Lee et al., 2009 [34].

C* = up-regulated in a daf-16-dependent fashion in daf-2 mutants Lee et al., 2009 [34].

D = down-regulated by DAF-12, Fisher and Lithgow, 2006 [30].

D* = up-regulated by DAF-12, Fisher and Lithgow, 2006 [30].

F = up-regulated during PA14 exposure, Shapira et al., 2006 [32].

F* = down-regulated during PA14 exposure, Shapira et al., 2006 [32].

G = up-regulated during PA14 exposure, Troemel et al., 2006 [33].

G* = down-regulated during PA14 exposure, Troemel et al., 2006 [33].

H = Von Stetina et al., 2007 [23].

(“Expressed”: genes whose expression is detected in the neurons, “Enriched”: genes that are solely or more highly expressed in neurons).

I = Pauli et al., 2006 [22].

(“Expressed”: genes whose expression is detected in the intestine, “Enriched”: genes that are solely or more highly expressed in intestine).