Table 1.
List of the most up- and downregulated (−) genes in ependymal cells from M. corti-infected brain in comparison to mock-infected brain samples
| Molecules | Fold change | Molecular function | Biological process |
|---|---|---|---|
| ARG1 |
142.1 |
Arginase activity |
Arginine and proline metabolism; urea cycle and metabolism of amino groups |
| CD74 |
126.8 |
MHC class II protein binding |
Antigen processing and presentation of exogenous peptide antigen via MHC class II |
| CCL8 |
83.18 |
Chemokine activity; heparin binding |
Cell-cell signaling; chemotaxis |
| SAA1 |
77.66 |
G-protein coupled receptor binding |
Acute-phase response; chemotaxis |
| PSMB9 |
74.76 |
Peptidase activity |
Antigen processing and presentation; aprotein polyubiquitination |
| HLA-C |
53.43 |
Beta-2-microglobulin binding; MHC class I receptor activity |
Antigen processing and presentation of peptide antigen via MHC class I |
| SRGN |
53.19 |
Collagen binding; protein binding |
Apoptotic process; biomineral tissue development; blood coagulation; maintenance of granzyme B location in T cell secretory granule |
| HLA-E |
39.98 |
MHC class I receptor activity |
Antigen processing and presentation of peptide antigen via MHC class I |
| HLA-B |
36.35 |
MHC class I receptor activity |
Antigen processing and presentation of peptide antigen via MHC class I |
| C3AR1 |
33.81 |
Complement component C3a receptor activity; G-protein coupled receptor activity; |
Chemotaxis; complement receptor-mediated signaling pathway |
| ST18 |
−23.92 |
DNA binding |
Regulation of transcription |
| ONECUT2 |
−20.08 |
Sequence-specific DNA binding transcription factor activity |
Cell fate commitment; cilium assembly; epithelial cell development |
| CEP76 |
−17.01 |
Protein binding |
Regulation of centriole replication |
| TNNT3 |
−11.99 |
Actin binding; calcium- dependent ATPase activity |
Muscle contraction; muscle filament sliding; regulation of ATPase activity |
| AZI2 |
−6.99 |
TBK1/IKKi-binding |
I-kappaB kinase/NF-kappaB cascade |
| METTL2B |
−6.85 |
Methyltransferase activity; transferase activity |
Methylation |
| PCF11 |
−6.8 |
RNA 3'-end processing |
Termination of RNA polymerase II transcription |
| C20ORF24 |
−6.67 |
ND |
ND |
| ACBD3 |
−6.37 |
Fatty-acyl-CoA binding |
Lipid biosynthetic process; steroid biosynthetic process; transport |
| SFRS8 | −5.65 | RNA binding | Negative regulation of nuclear mRNA splicing, regulation of transcription |
ND, not determined.