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. 2012 Dec 20;8(12):e1003090. doi: 10.1371/journal.pgen.1003090

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© 2012 Chan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In each study, the program MaCS [72] was used to simulate data, with sample size 22, for a 1 Mb region with the variable recombination map shown in red. (We used ; output was postprocessed to incorporate an empirical quadra-allelic mutation model.) Estimated recombination maps are shown in blue. The same block penalty of 50 was used in both cases. (A) The average recombination rate for the region is per kb, representative of the interior of the North American X. (B) The average recombination rate for the region is per kb, representative of the interior of the African X.

Inline graphic — In each study, the program MaCS [72] was used to simulate data, with sample size 22, for a 1 Mb region with the variable recombination map shown in red. (We used ; output was postprocessed to incorporate an empirical quadra-allelic mutation model.) Estimated recombination maps are shown in blue. The same block penalty of 50 was used in both cases. (A) The average recombination rate for the region is per kb, representative of the interior of the North American X. (B) The average recombination rate for the region is per kb, representative of the interior of the African X.