Table 2.
Cross-sectional associations between high sensitive C-Reactive Protein (CRP), Interleukin 6 (IL- 6), Prostaglandin F2 alpha (PGF2alpha), serum amyloid protein (SAA) and eGFRcystand albumin creatinine ratio (ACR) at age 77: Multivariable regression
| |
Cystatin C estimated glomerular filtration rate |
lnAlbumin creatinine ratio (ACR) |
||
|---|---|---|---|---|
| |
total cohort (n = 647) |
eGFR > 60 ml/min/1.73 m2(n = 514) |
total cohort (n = 647) |
ACR < 3 mg/mmol (n = 522) |
| β-coefficient (95% CI) | β-coefficient (95% CI) | β-coefficient (95% CI) | β-coefficient (95% CI) | |
|
Model A |
|
|
|
|
|
ln CRP (mg/L) |
−0.23 (−0.30 to −0.15)*** |
−0.10 (−0.17 to −0.34)** |
0.11 (0.03 to 0.19) ** |
0.07 (−0.04 to 0.06) |
|
ln PGF2α (nmol/mmol) |
−0.01 (−0.07 to 0.08) |
−0.01(−0.08 to −0.05) |
0.01 (−0.07 to 0.09) |
0.05 (0.002 to 0.10) * |
|
ln IL-6 (ng/L) |
−0.28 (−0.35 to −0.20)*** |
−0.10 (−0.17 to −0.04) ** |
0.13 (0.06 to 0.21) ** |
0.01 (−0.04 to 0.05) |
|
ln SAA (mg/L) |
−0.15 (−0.22 to-0.07)*** |
−0.05 (−0.12 to 0.02) |
0.14 (0.06 to 0.21) ** |
0.05 (0.002 to 0.10) * |
|
Model B (DAG adjusted) |
|
|
|
|
|
ln CRP (mg/L) |
−0.19 (−0.26 to −0.11)*** |
−0.09 (−0.16 to −0.02) ** |
0.09 (0.01 to 0.16) * |
−0.01 (−0.05 to 0.04) |
|
ln PGF2α (nmol/mmol) |
−0.01 (−0.07 to 0.08) |
−0.02 (−0.09 to 0.04) |
0.01 (−0.06 to 0.09) |
0.03 (−0.01 to 0.08) |
|
ln IL-6 (ng/L) |
−0.23 (−0.30 to −0.15) *** |
−0.09 (−0.16 to −0.02)* |
0.11 (0.03 to 0.19) ** |
−0.01 (−0.05 to 0.04) |
|
ln SAA (mg/L) |
−0.13 (−0.21 to −0.06)** |
−0.05 (−0.12 to 0.02) |
0.12 (0.05 to 0.20) ** |
0.04 (−0.008 to 0.09) |
|
Model C |
|
|
|
|
|
ln CRP (mg/L) |
−0.19 (−0.26 to −0.11)*** |
−0.09 (−0.16 to −0.02)** |
0.08 (0.01 to 0.16) * |
−0.01 (−0.06 to 0.04) |
|
ln PGF2α (nmol/mmol) |
−0.01 (−0.07 to 0.08) |
−0.02 (−0.09 to 0.04) |
−0.04 (−0.08 to 0.07) |
0.03 (−0.02 to 0.08) |
|
ln IL-6 (ng/L) |
−0.23 (−0.30 to −0.15)*** |
−0.09 (−0.16 to −0.02)** |
0.09 (0.01 to 0.16) * |
−0.01 (−0.06 to 0.04) |
| ln SAA (mg/L) | −0.13 (−0.21 to −0.06)*** | −0.05 (−0.12 to 0.02) | 0.11 (0.04 to 0.19) ** | 0.04 (−0.01 to 0.09) |
Data are regression coefficients for a 1-SD higher ln C-reactive protein (CRP), ln interleukin 6 (IL- 6), ln prostaglandin F2 ln α (PGF2α),ln serum amyloid protein A (SAA). Model A was adjusted for age; model B was adjusted according to directed acyclic graphs (DAG): age, BMI, smoking, systolic and diastolic blood pressure, LDL, HDL, and triglyceride, statin treatment, ACE inhibitor-, ASA-, anti-inflammation-, and cortisone medication. Model C was adjusted for: age, BMI, smoking, systolic and diastolic blood pressure, hypertension treatment, LDL, HDL, and triglyceride, statin treatment, diabetes, ACE inhibitor-, ASA-, anti-inflammation-, and corticosteroid treatment, and CVD. * p < 0.05, **p < 0.01. *** p < 0.001.