| Harling(2005) [17]
|
Single centre;Liverpool, UK |
RCT |
<31 weeksgestation |
50% (N = 26) versus100% oxygen(N = 26).No routineSpO2 monitoring. |
Both groups: Fixedoxygen concentrationdelivered for duration ofresuscitation until cardiorespiratory stabilityachieved and surfactantgiven. |
Death, Apgar score, CLD/BPD, ROP, NEC, need for long-term oxygen therapy |
| Saugstad(1998) [18]
|
11 centres inIndia, Egypt,Philippines,Estonia, Spain,Norway |
Quasi-RCT(alternatedate ofbirth) |
<37 weeksgestation |
Air (N = 75) versus100% oxygen(N = 72). Noroutine SpO2monitoring. |
Lower group: Oxygenlevel increased to 100%if infant unresponsiveafter 90 seconds. |
Death, Apgar score, proportion of infants reaching the target oxygen saturation All data obtained from authors |
| Lundstrøm(1995) [19]
|
Single centre; Copenhagen,Denmark |
RCT |
<33 weeksgestation |
Air (N = 34) versus80% oxygen (N = 6).No routineSpO2 monitoring. |
Lower group: FiO2increased in 0.1increments after oneminute in response toheart rate remaining‘below normal’. |
Death, Apgar score, receipt of surfactant, ROP, NEC, IVH, need for long-term oxygen therapy |
| Vento(2009) [20]
|
2 centres;Valencia, Spain |
RCT |
≤28 weeksgestation |
30% (N = 37) versus90% oxygen(N = 41). |
Both groups: FiO2titrated to achieve targetsaturations, 60–90seconds allowed forresponse after eachchange. If heart rate ≤60beats per minute for>30 s, oxygenconcentration increasedto 100% |
Death, Apgar score, receipt of intubation, receipt of surfactant, proportion of infants reaching the target oxygen saturation, CLD/BPD, ROP, NEC, IVH, duration of mechanical ventilation, duration of supplemental oxygen therapy, duration of hospital stay |
| Wang(2008) [21]
|
2 centres;San Diegoand Santa Clara,USA |
RCT |
<32 weeksgestation |
Air (N = 18)versus 100%oxygen (N = 23). |
Lower group: FiO2increased to 1.0 ifpersistent bradycardia orchest compression ormedication required.FiO2 was increased in0.25 increments ifSpO2<70% at 3 min or<85% at 5 min of lifeHigher group:Decreased FiO2 at 5 minif SpO2>95% |
Death, Apgar score, receipt of intubation, receipt of surfactant, IVH, duration of mechanical ventilation |
| Rabi(2011) [22]
|
Single-centre;Calgary, Canada |
RCT |
≤32 weeksgestation |
Air (N = 34)versus 100%(N = 72). |
Lower group: FiO2titrated in increments ofup to 0.2 every 15 s toachieve and maintaintarget saturations(85%–92% ). |
Death, Apgar score, receipt of intubation, proportion of infants reaching the target O2 saturation, CLD/BPD, duration of mechanical ventilation, duration of hospital stay |
