Table 4. Summary of Statistical Analysis of SRT2104 Pharmacokinetic Data: Day 28 vs Day 1.

		Geometric Least Square Means
SRT2104 Dose Level	Parameter	Day 1	Day 28	Day 28/Day 1 (90% C.I.)
0.5 g/day	Cmax (ng/ml)	326.22	199.12	61.04 (14.65–254.30)
	AUC(0-t) (ng.h/ml)	1950.07	1610.10	82.57 (34.83–195.70)
	AUC(0-∞) * (ng.h/ml)	2503.70	1612.40	64.40 (29.19–142.09)
2.0 g/day	Cmax (ng/ml)	301.28	389.50	129.28 (40.01–417.76)
	AUC(0-t) (ng.h/ml)	1743.14	3577.50	205.23 (79.36–530.77)
	AUC(0-∞) * (ng.h/ml)	1788.42	3669.38	205.17 (88.52–475.58)

^*AUC values included in the analysis are AUC_(0-∞) on Day 1 and AUC_(0-τ) on Day 28.

Results obtained from a mixed model ANOVA on log-transformed data with fixed effects of study day and gender and a random effect of subject.