Table 5. Summary of Statistical Analysis of SRT2104 Pharmacokinetic Data: Dose Proportionality.
| Study Day | SRT2104 Dose Level | Geometric Least Square Means | ||
| Geometric Least Square Means | % Ratio (90% C.I.) | |||
| Dose-Normalized Parameter | 0.5 g/day | 2.0 g/day | 2.0 g/0.5 g | |
| Day 1 | Cmax_D (ng/ml) | 215.74 | 69.64 | 32.28 (10.41–100.15) |
| AUC(0-t)_D (ng.h/ml) | 1297.86 | 516.59 | 39.80 (14.39–110.07) | |
| AUC(0-∞)_D (ng.h/ml) | 1754.57 | 504.43 | 28.75 (9.56–86.49) | |
| Day 28 | Cmax_D (ng/ml) | 206.06 | 96.83 | 46.99 (15.44–142.99) |
| AUC(0-t)_D (ng.h/ml) | 1548.09 | 911.01 | 58.85 (25.18–137.51) | |
| AUC(0-τ)_D (ng.h/ml) | 1548.74 | 909.85 | 58.75 (25.10–137.52) | |
| AUC(0-∞)_D (ng.h/ml) | 2636.12 | 1903.42 | 72.21 (33.02–157.88) | |
Results obtained from an ANOVA on dose-normalized (to 0.5 g) log-transformed data with fixed effects of dose level and gender.